TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3203547
Disease: Axial spondyloarthritis
Axial spondyloarthritis
0.100 Biomarker disease BEFREE • Maintaining stable dose of TNF-α inhibitor for long-term in axSpA may be relatively safe for managing atherogenic lipid. 31486930 2020
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 AlteredExpression disease BEFREE β4GalT1 promoted cell invasion, MMP-3 production, and the secretion of TNF-α, IL-1β, and IL-6. si-TNF-α attenuated the β4GalT1-enhanced cell invasion and inflammatory factor secretion in OA-FLS. 31210280 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression phenotype BEFREE β4GalT1 promoted cell invasion, MMP-3 production, and the secretion of TNF-α, IL-1β, and IL-6. si-TNF-α attenuated the β4GalT1-enhanced cell invasion and inflammatory factor secretion in OA-FLS. 31210280 2019
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma
0.070 Biomarker disease BEFREE β-TrCP1 promotes cell proliferation via TNF-dependent NF-κB activation in diffuse large B cell lymphoma. 31731887 2020
CUI: C0031090
Disease: Periodontal Diseases
Periodontal Diseases
0.100 AlteredExpression group BEFREE β-glucan reduced plasmatic levels of TNF-α in diabetic animals with PD and of IL-10 in animals with PD (<i>p</i> < 0.05). 28906456 2017
CUI: C0580174
Disease: Portal hypertensive gastropathy
Portal hypertensive gastropathy
0.010 AlteredExpression disease BEFREE β-arr1 limited the activation of p65 to repress TNF-α-induced inducible nitric oxide synthase (iNOS) expression and NO release, which could regulate ER stress/PUMA-mediated mucosal apoptosis in PHG. 26119788 2015
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.300 AlteredExpression disease BEFREE α<sub>1</sub>-adrenoceptor blockade, endothelial protection, TNF-α suppressing and antioxidant activity together with favorable pharmacokinetic parameters determines high efficacy of MH-76, leading to the effective improvement of hemodynamic and metabolic disturbances in metabolic syndrome. 31133498 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 AlteredExpression disease LHGDN [The postburn changes of the plasma levels of PGE2 and TNF alpha in burn patients]. 11774822 2001
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 AlteredExpression disease LHGDN [The effects of exercise training on plasma tumor necrosis factor-alpha, blood leucocyte and its components in congestive heart failure patients]. 12133434 2002
CUI: C0600327
Disease: Toxic Shock Syndrome
Toxic Shock Syndrome
0.540 Biomarker disease RGD [The effect of transmembrane- and secreted-tumor necrosis factor-alpha on shock liver]. 12622907 2002
CUI: C0019212
Disease: Hepatorenal Syndrome
Hepatorenal Syndrome
0.200 Biomarker disease RGD [Study on the expressions and roles of renal heat shock protein 72 and Toll-like receptor 4 in hepatorenal syndrome in rat]. 18093430 2007
CUI: C0024115
Disease: Lung diseases
Lung diseases
0.600 Biomarker group RGD [Studies on the expression of mRNA of anti- and pro-inflammatory cytokines in acute lung injury induced by lipopolysaccharide in rat]. 15461830 2004
CUI: C0017152
Disease: Gastritis
Gastritis
0.300 Therapeutic disease RGD [Serumimmunological study of moxibustion on helicobacter pylori gastritis in rats]. 25335260 2014
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker disease LHGDN [Role of TNF-alpha and cytokines in the physiopathology of rheumatoid arthritis. Therapeutic perspectives]. 14979058 2003
CUI: C0037116
Disease: Silicosis
Silicosis
0.300 Therapeutic disease RGD [Regulation of ursolic acid on TNF-alpha and collagen in silicotic rats]. 25199287 2014
CUI: C0021655
Disease: Insulin Resistance
Insulin Resistance
0.500 Biomarker phenotype CTD_human [Possible connection between ghrelin, resistin and TNF-alpha levels and the metabolic syndrome caused by atypical antipsychotics]. 16493877 2005
CUI: C0920563
Disease: Insulin Sensitivity
Insulin Sensitivity
0.300 Biomarker phenotype CTD_human [Possible connection between ghrelin, resistin and TNF-alpha levels and the metabolic syndrome caused by atypical antipsychotics]. 16493877 2005
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 GeneticVariation group LHGDN [Polymorphisms of tumor necrosis factor genes in sporadic and hereditary breast cancer]. 18416134 2007
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation disease LHGDN [Polymorphism of the tumor necrosis factor alpha gene in patients with infiltrative tuberculosis and from the Bashkorstan populations]. 12391840 2002
CUI: C0600452
Disease: Hepatopulmonary Syndrome
Hepatopulmonary Syndrome
0.200 Therapeutic disease RGD [Molecular mechanism of tumor necrosis factor-alpha monoclonal antibody in hepatopulmonary syndrome in rats]. 26236934 2015
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 Biomarker disease LHGDN [Expression of tumor necrosis factor-alpha and nuclear factor-kappa B in childhood ulcerative colitis]. 14731353 2003
CUI: C0021818
Disease: Intervertebral Disk Displacement
Intervertebral Disk Displacement
0.210 Biomarker disease RGD [Effects of sacral canal injection on nerve root local inflammatory factors in rat model with lumbar disc herniation]. 24826482 2014
FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 Therapeutic disease RGD [Effect of electroacupuncture stimulation of back-shu points on expression of TNF-alpha and lipid peroxidation reaction in the liver tissue in non-alcoholic fatty liver disease rats]. 25219124 2014
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 Therapeutic phenotype RGD [Effect of electroacupuncture stimulation of back-shu points on expression of TNF-alpha and lipid peroxidation reaction in the liver tissue in non-alcoholic fatty liver disease rats]. 25219124 2014
FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 2
0.200 Therapeutic phenotype RGD [Effect of electroacupuncture stimulation of back-shu points on expression of TNF-alpha and lipid peroxidation reaction in the liver tissue in non-alcoholic fatty liver disease rats]. 25219124 2014